Stanford RNA Medicine Program
Who We Are
The Stanford RNA Medicine Program (RAMP) laboratory is at the forefront of advancing RNA-based research by providing cutting-edge technology support and resources. Our lab specializes in RNA functional element design, functional screens, RNA purification, and innovative delivery technologies, including lipid nanoparticles (LNP). The mission of RAMP is to bridge the gap between scientific discovery and clinical application, driving breakthroughs in precision medicine.
Our Process
A comprehensive, end-to-end workflow designed to accelerate discovery and ensure robust, reproducible results.
Step 1
Mining viral genomes for functional RNA elements
Step 2
High-throughput cloning to generate complex RNA libraries
Step 3
Industry-grade production and purification of RNA
Step 4
Formulation with a variety of LNP compositions
Step 5
In vitro and in vivo testing to assess function
Step 6
Data fed into sequence and structure to function modeling
RNA Platforms
We leverage a spectrum of RNA technologies, from established platforms to next-generation systems, to achieve optimal therapeutic outcomes.
Established
mRNA
Established RNA technology, high expression with a wide range of applications.
Next Generation
Self amplifying RNA
Next generation technology, RNA with high expression at lower dose.
Next Generation
Circular RNA
Next generation technology, RNA with longer duration of expression.
Therapeutic Applications
Our platforms are versatile and can be applied across a broad range of therapeutic areas to address significant unmet medical needs.
Antigen discovery
Inflammation
Protein replacement therapies
Gene editing
Therapeutic delivery technologies
Cancer vaccines
Infectious disease vaccines
Capabilities
The RAMP Program is committed to groundbreaking discoveries and advancements in the field of medicine.
Our lab is equipped with advanced instrumentation
that supports a wide range of research, including:
Agilent HPLC 1260 Infinity II
Precise RNA and nucleic acid purification at prep or semi-prep scales.
Precision Nanosystems NanoAssemblr Ignite
Formulation of lipid nanoparticles.
Wyatt Technology DynaPro Plate Reader III
Assessment of size and stability of RNA and nanoparticle formulations.
Eppendorf Vacufuge Plus
Accelerates the evaporation of solvents under reduced pressure, allowing for rapid concentration without compromising sample integrity.
RNA Immunogenicity Assays
Evaluate immune response, assess the safety and efficacy of RNA constructs, and provide critical data for regulatory submissions.